Proteoforms Are the Next New Wave of Innovation and Biology

CPSA Analytics 2021 Imagine Summit

Brad Ackermann, Eli Lilly and Company

Proteins matter. Proteins matter more than any other molecule.” – Brad Ackermann, Eli Lilly and Company

Brad takes us on a tour of the importance of proteins for the understanding and treatment of disease – 99% of drug targets are proteins. The subtle differences in proteoforms and how they associate are not readily differentiated without the use of reliable platforms utilising liquid chromatography combined with mass spectrometry. Furthermore, in order to more fully understand biology we need to understand proteoforms in tissues, in addition to what is in circulation. Brad made it clear that the needs of the 3P’s (Patient, Physician and Payer) are paramount for the delivery of the healthcare of the future.